They were modified by adding various spacer arms of many size ending with carboxylic acid or alcohol groups. The key-intermediate -CD derivatives were synthesized by chemical way from -CD. We reported here different results of synthesis of such molecules by chemo-enzymatic way. Indeed, this is the most difficult barrier to pass through for active compounds. The final objects could be of importance to transport or target biologically relevant molecules such as drugs through blood-brain barrier. The aim of these investigations is in both cases to combine the size specificity of cyclodextrins for guests and their capacity to vectorize them. Since many years, special attention and efforts have been made to prepare amphiphilic cyclodextrins (CD) with the aim to obtain supramolecular assemblies as such or in the presence of preformed lipidic structures.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |